The ninth-seeded Saint Louis Billikens clash with the top-seeded Michigan Wolverines in the second round of the 2026 NCAA Tournament Midwest Region on Saturday. Saint Louis advanced with a convincing 102-77 win over eighth-seeded Georgia on Thursday, while Michigan cruised to a 101-80 win over 16tth-seeded Howard. The Billikens (29-5), who tied with VCU for the Atlantic 10 regular-season title at 15-3, have won 23 games by double digits this season. The Wolverines (32-3), who won the Big Ten regular-season crown at 19-1, have won seven of their past eight games.
Tip-off from KeyBank Center in Buffalo, N.Y., is set for 12:10 p.m. ET. Michigan is a 12.5-point favorite in the latest Saint Louis vs. Michigan odds, while the over/under for total points scored is 161.5. Before making any Michigan vs. Saint Louis picks, check out the Saint Louis vs. Michigan predictions from the SportsLine Projection Model.
The SportsLine Projection Model simulates every college basketball game 10,000 times. It entered the 2026 NCAA Tournament on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on a 28-22 run on top-rated CBB side picks.
Now, the model has simulated Saint Louis vs. Michigan 10,000 times and just revealed its college basketball picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several college basketball odds and college basketball lines for Michigan vs. Saint Louis:
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Saint Louis vs. Michigan spread: |
Michigan -12.5 |
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Saint Louis vs. Michigan over/under: |
161.5 points |
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Saint Louis vs. Michigan money line: |
Michigan -901, Saint Louis +591 |
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Saint Louis vs. Michigan picks: |
See picks at SportsLine |
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Saint Louis vs. Michigan TV: |
CBS |
Top Saint Louis vs. Michigan predictions
After 10,000 simulations of Saint Louis vs. Michigan, SportsLine’s model is going Under on the total (161.5 points). The Under has hit in six of the last 10 Saint Louis games, and in six of the last nine Michigan games. Saint Louis is 4-6 against the spread in its last 10 games. Michigan is 2-8 ATS in its last 10.
The model projects the Billikens to have four players score 10.6 points or more, including Robbie Avila, who is projected to score 14.5 points. The Wolverines are projected to have five players score 10.1 points or more, led by Yaxel Lendeborg, who is projected to score 17.1 points. The model is projecting 160 combined points. You can get the spread pick at SportsLine.
How to make Michigan vs. Saint Louis picks
Now, the model simulated every possession of Michigan vs. Saint Louis 10,000 times and says one side of the spread hits nearly 70% of the time. You can only see that pick at SportsLine.
So who wins Michigan vs. Saint Louis, and which side of the spread hits nearly 70% of the time? Visit SportsLine now to see which side of the Saint Louis vs. Michigan spread to back, all from the advanced model that just simulated this game 10,000 times, and find out.
