Kansas vs. Iowa State prediction, odds, spread, time: 2026 college basketball picks from proven model

Top-10 teams clash when the No. 9 Kansas Jayhawks battle the fifth-ranked Iowa State Cyclones in a key Big 12  matchup on Saturday. Kansas is coming off an 82-78 win over top-ranked Arizona on Monday, while Iowa State dropped a 62-55 decision at TCU on Tuesday. The Jayhawks (19-5, 9-2 Big 12), who have won eight in a row, are 4-3 on the road this season. The Cyclones (21-3, 8-3 Big 12), who are 2-0 against ranked opponents, are 13-0 on their home court. Kansas star freshman Darryn Peterson is expected to play after missing Monday’s game (illness).

Tipoff from the Hilton Coliseum in Ames, Iowa, is set for 1 p.m. ET. Kansas leads the all-time series 191-69, including an 84-63 win on Jan. 13. Iowa State is a 7.5-point favorite in the latest Kansas vs. Iowa State odds from DraftKings Sportsbook, while the over/under for total points scored is 146.5. Before making any Iowa State vs. Kansas picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 15 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on an 11-5 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Kansas vs. Iowa State 10,000 times and just revealed its coveted men’s college basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting lines for Kansas vs. Iowa State:

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How to make Kansas vs. Iowa State picks

SportsLine’s model is going Over on the total (146.5 points). The Over has hit in two of the last four Kansas games, and in two of the last four Iowa State matchups. 

The model projects the Jayhawks to have four players score 12.9 points or more, including Peterson’s projected 17.9 points. The Cyclones are projected to have three players score 14.5 or more points, led by Joshua Jefferson, who is projected to score 17.9 points. The Over clears in more than 60% of simulations. 

The model also says one side of the spread hits nearly 60% of the time. You can only see that pick at SportsLine.

So who wins Kansas vs. Iowa State, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the Kansas vs. Iowa State spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.