Cavaliers vs. Pistons prediction, odds, spread, line, time: 2026 NBA picks for Friday, Feb. 27

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Two of the hottest teams in the Eastern Conference clash when the Cleveland Cavaliers battle the Detroit Pistons in a matchup of the top two teams in the NBA’s Central Division on Friday. Cleveland, which has won eight of 10, dropped a 118-116 decision at Milwaukee on Wednesday, while Detroit, also 8-2 in its past 10, defeated Oklahoma City 124-116 that same night. The Cavaliers (37-23), the fourth seed in the East, are 17-12 on the road this season. The Pistons (43-14), the top seed in the conference, are 22-7 on their home court. James Harden (thumb) is questionable for Cleveland, while Donovan Mitchell (groin) has been ruled out. Isaiah Stewart (league suspension) remains out for Detroit.

Tipoff from Little Caesars Arena in Detroit is set for 7 p.m. ET. The Pistons are 5.5-point favorites in the latest Cavaliers vs. Pistons odds from DraftKings Sportsbook, while the over/under for total points scored is 227.5, up two points from the opener. Before making any Pistons vs. Cavaliers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

New users can target the DraftKings promo code, which offers $200 in bonus bets if your first $5+ bet wins:

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model entered Week 19 on a sizzling 38-18 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Cavaliers vs. Pistons 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Pistons vs. Cavaliers:

Cavaliers vs. Pistons spread:    

Detroit -5.5 at DraftKings    

Cavaliers vs. Pistons over/under:    

227.5 points

Cavaliers vs. Pistons money line:    

Detroit -229, Cleveland +188

Cavaliers vs. Pistons picks:    

See picks at SportsLine

Cavaliers vs. Pistons streaming:

Fubo (Try for free) 

New users can also target the latest Underdog promo code CBSSPORTS2, good for $75 in fantasy bonus entries when you play $5 in select states.

Top Cavaliers vs. Pistons predictions

After 10,000 simulations of Cavaliers vs. Pistons, SportsLine’s model is going Under on the total (227.5). The Under has hit in eight of the past 10 head-to-head matchups between the teams. The Under has hit in four of the past seven Detroit games. The Cavaliers are 6-4 against the spread in their last 10 games. The Pistons, meanwhile, are 5-2 ATS in their last seven.

The SportsLine model is projecting the Cavaliers’ James Harden to score 19.3 points on average and be one of six Cleveland players to score 10.5 or more points. The Pistons’ Cade Cunningham, meanwhile, is projected to have 25 points as four Detroit players score 12.2 points or more. The teams are projected to combine for 225 points.

How to make Pistons vs. Cavaliers picks

The model also says one side of the spread hits more than 50% of the time. You can head to SportsLine to see the model’s NBA picks

So who wins Pistons vs. Cavaliers, and which side of the spread hits more than 50% of the time? Visit SportsLine now to see which side of the Cavaliers vs. Pistons spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.





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